J Korean Orthop Res Soc.  2003 Oct;6(2):170-176.

Expression of Vascular Endothelial Growth Factor in Diabetic Frozen shoulder

• Kim YH
• Kwon SY
• Kim JY
• Park IJ
• Cho YK
• Han CW

Abstract

PURPOSE
To investigate the expression of Vascular Endothelial Growth Factor (VEGF) in diabetic frozen shoulders.
MATERIALS AND METHODS
We preformed arthroscopic adhesiolysis on 9 diabetic frozen shoulder patients, and observed the arthroscopic findings. Also, we examined the potential role of VEGF by using samples of synovial tissues from 5 patients, and 2 normal synovial tissues. Immunohistochemical staining and Western blotting were performed using polyclonal antibodies against VEGF.
RESULTS
There was hyperemic synovitis in the 9 diabetic frozen shoulder patients. In the 5 patients' tissue samples, there was strong immunostaining and expression to VEGF, but there was little staining and expression in the control group.
CONCLUSION
We postulate that VEGF is synthesized and secreted in the synovium of diabetic frozen shoulders and that secreted VEGF binds specific receptors on the endothelial cells of nearby small blood vessels, and leads to the subsequent development of frozen shoulders in diabetic patients.

Keyword

Diabetic Frozen Shoulder; VEGF

MeSH Terms

Antibodies
Blood Vessels
Blotting, Western
Bursitis*
Endothelial Cells
Humans
Shoulder
Synovial Membrane
Synovitis
Vascular Endothelial Growth Factor A*
Antibodies
Vascular Endothelial Growth Factor A