J Korean Radiol Soc.  2003 Feb;48(2):181-187. 10.3348/jkrs.2003.48.2.181.

The Study of Renal Perfusion Image in Rabbit by Harmonic Ultrasound with Microbble Contrast Agent in Comparison with 99mTc-DTPA: Focusing on US Scan Technique and Concentration of Contrast Agent

• Eun HW
• Kim JH
• Choi JH
• Lee HJ
• Bae IY
• Rhee CS
• Suh JS

• KMID: 2103722
• DOI: http://doi.org/10.3348/jkrs.2003.48.2.181

Abstract

PURPOSE
To compare the results of harmonic ultrasound (US) renal perfusion imaging using 99mTc-DTPA as contrast agent with those obtained when a microbubble contrast medium was used.
MATERIALS AND METHODS
Twenty rabbits underwent harmonic US renal perfusion imaging using 99mTc-DTPA as contrast agent, and the imaging procedure was then repeated using a microbubble contrast medium. Three different concentrations of contrast media (200, 300 and 400 mg/ml) and two different scanning techniques (intermittent and continuous) were used, and the images obtained were assessed using six different methods. By means of a computer program, the images were converted to a renal perfusion curve and Tpeak values were calculated. Images obtained after use of the two different contrast media were compared.
RESULTS
Tpeak at renal perfusion imaging using 99mTc-DTPA was 6.3+/-0.9 sec, and where microbubble contrast agent was used, the findings were was as follows: 13.8+/-1.6 sec (method 1), 6.5+/-1.1 sec (method 2), 14.8+/-1.7 sec (method 3), 6.6+/-1.0 sec (method 4), 15.2+/-2.0 sec (method 5), 6.4+/-0.7 sec (method 6). Method 6 had the highest correlation coefficients.
CONCLUSION
In conclusion, the harmonic ultrasound renal perfusion images acquired using 99mTc-DTPA were similar to those obtained using microbubble contrast agent. Continuous scanning techniques showed correlation.

Keyword

Ultrasound (US), contrast media; Kidney, radionuclide studies

MeSH Terms

Contrast Media
Microbubbles
Perfusion Imaging
Perfusion*
Rabbits
Ultrasonography*
Contrast Media