J Korean Soc Coloproctol.  2012 Dec;28(6):294-298. 10.3393/jksc.2012.28.6.294.

Association of Immune Status with Recurrent Anal Condylomata in Human Immunodeficiency Virus-Positive Patients

• Sung JH
• Ahn EJ
• Oh HK
• Park SH

• KMID: 2101599
• DOI: http://doi.org/10.3393/jksc.2012.28.6.294

Abstract

PURPOSE
An anal condyloma is a proliferative disease of the genital epithelium caused by the human papillomavirus. This condition is most commonly seen in male homosexuals and is frequently recurrent. Some reports have suggested that immunosuppression is a risk factor for recurrence of a condyloma. Thus, we investigated the risk factors for a recurrent anal condyloma in human immunodeficiency virus (HIV)-positive patients.
METHODS
We retrospectively analyzed 85 consecutive patients who were diagnosed with and underwent surgery for an anal condyloma from January 2007 to December 2011. Outcomes were analyzed based clinical and immunologic data.
RESULTS
Recurrent anal condylomata were found in 25 patients (29.4%). Ten cases (40.0%) were within postoperative 3 months. At postoperative 6 months, the CD4 lymphocyte count in the recurrent group was lower than it was in the nonrecurrent group (P = 0.023).
CONCLUSION
CD4-mediated immunosuppression is a risk factor for recurrent anal condylomata in HIV-positive patients.

Keyword

Condyloma accuminata; Human papillomavirus; HIV; Recurrence; Immunosuppression

MeSH Terms

CD4 Lymphocyte Count
Epithelium
HIV
Homosexuality
Humans
Immunosuppression
Male
Recurrence
Retrospective Studies
Risk Factors