J Korean Soc Coloproctol.
2008 Aug;24(4):265-272. 10.3393/jksc.2008.24.4.265.
Colorectal Cancer Presenting as an Early Recurrence Within 1 Year after a Curative Resection
- Affiliations
-
- 1Department of Surgery, Yeungnam University School of Medicine, Daegu, Korea.
- 2Department of Surgery and Colorectal Clinic, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. hckim@skku.edu
- 3Department of Radiology and Colorectal Clinic, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
- KMID: 2101458
- DOI: http://doi.org/10.3393/jksc.2008.24.4.265
Abstract
-
PURPOSE: An individualized surveillance protocol based on stratified prognostic factors is needed for the early detection of recurrent disease. The aim of this study was to determine both the clinicopathological characteristics for early-recurring colorectal cancer and the impact on survival.
METHODS
From January 1996 to September 2000, 1,504 patients with curatively resected colorectal cancer were recruited. The primary goal of this study was to evaluate the time interval until first loco-regional or distant recurrence, and the secondary goal was the last survival status. Early recurrence was defined as recurrence within the first 12 months postoperatively. Clinicopathologic data and preoperative CT records were reviewed. The follow-up period was over 48 months.
RESULTS
The 5-year recurrence rate was 25.4%, and 39.5% of these were detected within the first 12 months postoperatively. In the multivariate analysis, the independent prognostic factors for early recurrence were cell differentiation (PD/MUC/SRC), lymphovascular invasion, and absence of adjuvant chemotherapy in stage III and curatively resected colorectal cancer in stage IV. Inaccurate interpretation by a low-quality CT scan resulted in a stage III cancer being understaged preoperatively. The 5-year overall survival rate according to the recurrent time interval was significantly different (early recurrence: 7.4% vs. late recurrence: 23.6%, P<0.05). The resection rate was similar in both groups (early recurrence: 22.7% vs. late recurrence: 27.6%, P=0.392).
CONCLUSIONS
Colorectal cancer that recurred within 12 months showed more aggressive biologic behaviors and poor survival. Understaging caused by incomplete preoperative evaluation for disease extension may cause treatment failure.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- CT Findings of Locoregional Recurrence after Curative Resection of Colorectal Cancer
- Predictive factors and the prognosis of recurrence of colorectal cancer within 2 years after curative resection
- Carcinoembryonic Antigen-Directed Second Look Operation in Recurrent Colorectal Cancer
- Clinicopathologic Evaluation of Patients with Recurrence of Gastric Cancer within 6 Months after Curative Resection
- Biliary Tract and Pancreas: Survival and Recurrence Pattern after Curative Resection of Pancreatic Cancer
