J Korean Soc Neonatol.  1999 Nov;6(2):154-161.

Comparison of Synthetic Surfactant with Modified Bovine Surfactant in Neonatal Respiratory Distress Syndrome

Affiliations
  • 1Department of Pediatrics, Sung Kyun Kwan University College of Medicine, Seoul, Korea.

Abstract

PROPOSE: This study was designed to compare the efficacy of a synthetic surfactant (Exosurf) and a modified bovine surfactant (SurfactenR) in the treatment of neonatal respiratory distress syndrome.
METHODS
A total of 90 infants with respiratory distress syndrome who were admitted to neonatal intensive care unit at Samsung Medical Center between October 1994 to September 1996 were includeeach surfactant.
RESULTS
There was no significant difference in between two groups regarding birth weight, gestational age, and initiation of treatment after birth. ExosurfR group received less supplemental oxygen therapy and ventilator care. Survival rate were 81.3R in Exosurf group and 79.2% in SurfactenR group. The incidences of patent ctus arteriosus in the ExosurfR and SurfactenR groups were 75% and 62.5%, grade 3-4 intcular hemorrhage were 18.8% and 10.4%, respectively,' retinopathy of prematurity were 9.4% and 18.8%, respectively. There was significant improvernent of a/APO2 and VI at 30 minutes and 2 hours after the treatment in SurfactenR group', 2 hours and 6 hours after the treatment in ExosurfR group, however, dynamic compliance and respiratory resistance did not improve during 24 hours.
CONCLUSION
Although SurfactenR treatment appears to induce faster improvement in oxygenation and pulmonary function than ExosurfR treatment, this study does not reveal any difference in clinical outcomes among those who received two different surfactant preparations.

Keyword

Synthetic surfactant; Modified bovine surfactant; Respiratory Distress Syndrome

MeSH Terms

Birth Weight
Compliance
Gestational Age
Hemorrhage
Humans
Incidence
Infant
Infant, Newborn
Intensive Care, Neonatal
Oxygen
Parturition
Respiratory Distress Syndrome, Newborn*
Retinopathy of Prematurity
Survival Rate
Ventilators, Mechanical
Oxygen
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