J Korean Soc Pediatr Nephrol.  1998 May;2(1):50-59.

Clinicopathologic Features and HBsAg and HBeAg Expressions in Hepatitis B Virus-associated Glomerulopathy

• Yoon HK
• Chung WY
• Jung SJ
• Kim YH
• Kim SY

Abstract

Morphometry of nuclei of the benign and malignant prostatic lesions was performed to study the relationship between nuclear size and shape and the prognosis of prostatic adenocarcinoma. Fifty one cases of prostatic adenocarcinoma and 13 cases of benign prostatic hyperplasia were included to evaluate area, perimeter, Dmax, Dmin, and 5 form factors of the nuclei by image analyzer (Zeiss Ibas 2000) using hematoxylin-eosin stained slides. All analytic factors of nuclear size and shape were significantly different between benign lesions and adenocarcinomas. Increased nuclear size was associated with nu- clear irregularity, presence of metastasis, advanced clinical stage, and high Gleason's grade and score of prostatic adenocarcinoma. On Kaplan-Meier method, survival was decreased with older age, no hormonal treatment, stage D, high Gleason's grade and stage as well as with larger size and irregular shape of the nuclei. In conclusion, morphometry of nuclei of the prostate can be a helpful tool to differentiate between benign and malignant lesions. Nuclear morphology is thought to be associated with prognosis of prostatic adenocarcinoma.

Keyword

Breast; Fibroadenoma; Proliferative breast lesions with atypia; Fine needle aspiration cytology, Overdiagnosis; Overdiagnosis

MeSH Terms

Adenocarcinoma
Breast
Fibroadenoma
Hepatitis B e Antigens*
Hepatitis B Surface Antigens*
Hepatitis B*
Hepatitis*
Neoplasm Metastasis
Prognosis
Prostate
Prostatic Hyperplasia
Hepatitis B Surface Antigens
Hepatitis B e Antigens