J Korean Soc Radiol.  2011 Mar;64(3):261-264. 10.3348/jksr.2011.64.3.261.

Amyloidoma of Retroperitoneal Lymph Nodes: A Case Report

Affiliations
  • 1Department of Radiology, College of Medicine, Hanyang University, Korea. songsy01@gmail.com
  • 2Department of Radiology, College of Medicine, Hanyang University Guri Hospital, Korea.
  • 3Department of Pathology, Hanyang University Hospital, College of Medicine, Korea.

Abstract

Herein we report a case of retroperitoneal amyloidoma in a 56-year-old man and to describe its imaging findings and pathologic features. Abdomen computed tomography showed multiple nodular masses with amorphous calcifications in the retroperitoneum. On histologic review, these masses were composed of extensive nodular deposition of irregularly shaped amorphous eosinophilic material that was strongly positive on Congo red staining and apple green birefringence under polarizing microscopy, which is diagnostic for amyloidosis.


MeSH Terms

Abdomen
Amyloidosis
Birefringence
Congo Red
Eosinophils
Humans
Microscopy
Middle Aged
Retroperitoneal Space
Tomography, X-Ray Computed
Congo Red

Figure

  • Fig. 1 A. An axial CT scan obtained at the level of the inferior pole of the right kidney. There are multiple nodular masses (see white arrows) around retroperitoneal great vessels with amorphous calcifications and surrounding infiltrations of low attenuation. B. At the level of the pelvic cavity, on axial CT image, an inhomogeneous enhancement pattern of amyloidoma is noted. C. Microscopic findings revealed a well demarcated mass that was composed of nodular depositions of irregularly shaped amorphous pale eosinophilic materials (see black arrows) and foci of calcification (H & E, ×200). These amyloid deposits were surrounded by multinucleated giant cells, histiocytes, lymphocytes, plasma cells, and ossification in dense fibrous stroma. D. Amyloid deposits were strongly positive on Congo red staining (×200). E. There is 'apple green' birefringence (white arrow) under polarizing microscopy (×200).


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