J Rhinol.  2023 Nov;30(3):177-180. 10.18787/jr.2023.00043.

A Case of Bilateral Trigeminal Amyloidoma Diagnosed Through an Endoscopic Transsphenoidal Approach

• Park SI
• Ryu G

• KMID: 2548197
• DOI: http://doi.org/10.18787/jr.2023.00043

Abstract

Amyloidosis is a systemic disease characterized by the accumulation of amyloid protein in multiple organs. Amyloidoma, in contrast, is an uncommon localized form of amyloidosis that presents as a single mass or tumor-like lesion. Primary amyloidoma in the central nervous system is rare, and only a few cases have been reported. Notably, the Gasserian ganglion is the most frequently affected site of amyloidoma in the central nervous system, and progressive trigeminal neuropathy is a characteristic finding. Among these cases, the bilateral occurrence of amyloidoma is exceedingly rare. In this report, we present the case of a 51-year-old woman diagnosed with bilateral trigeminal amyloidoma, confirmed by an endoscopic biopsy via the transsphenoidal approach.

Keyword

Amyloidoma; Trigeminal nerve; Gasserian ganglion; Skull base

Figure

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  Fig. 1. Magnetic resonance imaging of the bilateral Meckel’s cave. A: Axial contrast-enhanced T1-weighted image displaying involvement of bilateral Meckel’s cave (yellow arrows). B: T2-weighted image showing iso- to low-signal intensity (yellow arrows).

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  Fig. 2. Paranasal sinus contrast-enhanced computed tomography scan showing a poorly enhancing soft-tissue lesion in the bilateral Meckel’s cave. A: Axial view. B: Coronal view.

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  Fig. 3. Hematoxylin and eosin-stained histologic sections demonstrate abundant amorphous eosinophilic material suspicious for amyloid.

Reference

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