J Korean Soc Spine Surg.  2008 Jun;15(2):111-114. 10.4184/jkss.2008.15.2.111.

Spontaneous Spinal Epidural Hematoma after use of Anticoagulation Therapy

Affiliations
  • 1Department of Orthopedic Surgery, Bundang Jaesang General Hospital, Seongnam, Korea. w00wa@dmc.or.kr

Abstract

Spontaneous epidural hematoma (SEH) is an uncommon cause of spinal cord compression. It tends to occur in patients at high risk for hemorrhage. Various medications are associated with SEH, including antiplatelet agents, anticoagulants, and thrombolytics. Because patients usually present with neurologic deficits, early diagnosis and proper management are required to achieve full recovery. The principal management is surgical evacuation of the SEH via laminectomy. We present a case of a 51-year-old woman on both oral aspirin and intravenous heparin who subsequently developed a SEH.

Keyword

Spinal cord compression; Epidural hematoma; Anticoagulants; Hematoma; Laminectomy

MeSH Terms

Anticoagulants
Aspirin
Early Diagnosis
Female
Hematoma
Hematoma, Epidural, Spinal
Hemorrhage
Heparin
Humans
Laminectomy
Middle Aged
Neurologic Manifestations
Platelet Aggregation Inhibitors
Spinal Cord Compression
Anticoagulants
Aspirin
Heparin
Platelet Aggregation Inhibitors

Figure

  • Fig. 1. (A) T1-weighted sagittal and axial image of the thoracolumbar spine shows a posterior epidural intermediate signal intensity at T12-L5 level. (B) T2-weighted sagittal and axial image of the thoracolumbar spine shows the high signal intensity suggesting hematoma.

  • Fig. 2. (A) Intraoperative field image of thoracolumbar spine shows that fill with hematoma (arrow) in epidural space. (B) Intraoperative field image of thoracolumbar spine after evacuation of hematoma.


Reference

1). Jackson R. Case of spinal apoplexy. Lancet. 1869; 2:5–6. (cited from Locke GE, Giorgio AJ, Biggers SL, Johnson AP, Salem F: Acute spinal epidural hematoma secondary to aspirin-induced prolonged bleeding. Surg Neurol 1976;5: 293-296.).
Article
2). Park HJ, Jeon JS. Spontaneous Thoracic Spinal Epidural Hematoma after use of anticoagulants. J Korean Spine Surg Soc. 2004; 11:125–129.
3). Kim HJ, Hwang SH, Park IS, et al. Spontaneous Spinal Epidural Hematoma with Intraoperative Acute Massive Bleeding. J Korean Neurosurg Soc. 2000; 29:1184–1187.
4). Harik SI, Raichle ME, Reis DJ. Spontaneously remitting spinal epidural hematoma in a patient on anticoagulants. New Engl J Med. 1971; 284:1355–1357.
Article
5). Mustafa MH, Gallino R. Spontaneous spinal epidural hematoma causing cord compression after streptokinase and heparin therapy for acute coronary artery occlusion. South Med J. 1988; 81:1202–1203.
Article
6). Chan KC, Wu DJ, Ueng KC, et al. Spinal epidural hematoma following tissue plasminogen activator and heparinization for acute myocardial infarction. Jpn Heart J. 2002; 43:417–421.
Article
7). Zielinski CJ, Colwell CW, Collis DK, et al. Hematoma as a Complication of Enoxaparin Use. J Bone Joint Surg AM. 2000; 82:1357–1365.
Article
8). Zilkha A, Irwin GA, Fagelman D. Computed tomography of spinal epidural hematoma. AJNR Am J Neuroradiol. 1983; 4:1073–1076.
9). Rebello MD, Dastur HM. Spinal epidural hemorrhage: A review and two case reports. Neurol India. 1966; 14:135–145.
10). Lawton MT, Porter RW, Heiserman JE, et al. Surgical management of spinal epidural hematoma. relationship between surgical timing and neurological outcome. J Neurosurg. 1995; 83:1–7.
Article
Full Text Links
  • JKSS
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr