J Korean Surg Soc.  2010 Dec;79(6):503-507. 10.4174/jkss.2010.79.6.503.

Dermatofibrosarcoma Protuberans in Abdominal Wall Aggravated during Pregnancy

• Hwang KT
• Chung JK
• Jung IM
• Heo SC
• Ahn YJ
• Ahn HS
• Chang MS
• Kim BJ

• KMID: 2096609
• DOI: http://doi.org/10.4174/jkss.2010.79.6.503

Abstract

Dermatofibrosarcoma protuberans is a rare tumor that occurs in the dermis or subcutaneous tissue of the trunk or extremities in relatively young adults. There are few reports of Dermatofibrosarcoma protuberans associated with pregnancy. We experienced a 28-year-old pregnant female patient with an abdominal wall mass, which grew rapidly during pregnancy. Excisional biopsy was performed and the pathologic diagnosis was fibrosarcoma transformed from Dermatofibrosarcoma protuberans. Dermatofibrosarcoma protuberans showed a positive CD34 immunostaining while fibrosarcoma showed a negative CD34. There was no recurrence or metastasis with the follow up period of 2 years. We report here a rare case of Dermatofibrosarcoma protuberans aggravated during pregnancy with a review of the literature.

Keyword

Abdominal wall; Dermatofibrosarcoma; Pregnancy

MeSH Terms

Abdominal Wall
Adult
Biopsy
Dermatofibrosarcoma
Dermis
Extremities
Female
Fibrosarcoma
Follow-Up Studies
Humans
Neoplasm Metastasis
Pregnancy
Recurrence
Subcutaneous Tissue
Young Adult
Dermatofibrosarcoma

Figure

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  Fig. 1 Gross appearance of dermatofibrosarcoma protuberans.Two nodules abut each other and the total lesion is 5.0×4.5×3.5 cm in three dimensions. The upper right portion involving the skin dermis and subcutis has firm consistency, and shows a pale-gray homogeneous and solid cut surface. In the lower left portion of the lesion, an ovoid smooth solid and rubbery nodule is exhibited and the tumor size is 3.5× 2.4 cm in surface dimension.

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  Fig. 2 Microscopic findings of dermatofibrosarcoma protuberans. Dermatofibrosarcoma portion composed of slender spindle cells is arranged in a storiform pattern. This portion intricately interdigitates with normal fat. H&E staining, ×100 (A). A high power view shows a uniform population of slender fibroblasts, an inconspicuous vasculature and interdigitating normal fat cells. H&E staining, ×400 (B). Fibrosarcoma area shows increased cellularity with a long fascicle pattern. H&E staining, ×100 (C). A high power view shows frequent mitotic figures (red circles). H&E staining, ×400 (D).

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  Fig. 3 Microscopic findings of the transitional zone. Dermatofibrosarcoma protuberans (upper right portion) showing the transition to fibrosarcoma (lower left corner). H&E staining, ×40 (A). Dermatofibrosarcoma protuberans (upper right) shows positive CD34 immunostain result while fibrosarcoma (lower left) shows negative CD34 immunoreactivity ×40 (B).

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