J Lipid Atheroscler.  2013 Jun;2(1):19-26. 10.12997/jla.2013.2.1.19.

Effect of Fenofibrate Therapy on Blood Creatinine Levels in Patients with Hypertension and Hypertriglyceridemia

Affiliations
  • 1Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul, Korea. cjkim@cau.ac.kr

Abstract


OBJECTIVE
Previous studies have reported that fenofibrate therapy increased blood creatinine levels. We investigated the effect of fenofibrate therapy on creatinine levels in patients with hypertension and hypertriglyceridemia.
METHODS
This retrospective study included 36 hypertensive patients with hypertriglyceridemia taking fenofibrate for 1-3 years (Fenofibrate group) and 36 control patients with similar age, sex, follow-up duration, creatinine levels, and lipid levels to those of fenofibrate therapy (Control group).
RESULTS
Baseline parameters except lipid profiles were similar between the fenofibrate and control groups. Creatinine levels increased in the fenofibrate group (from 0.90+/-0.18 mg/dL to 1.05+/-0.22 mg/dL, p<0.001) and did not change in the control group (from 0.91+/-0.12 mg/dL to 0.92+/-0.14 mg/dL, p=0.39). The elevation was more pronounced in the fenofibrate group than in the control group (0.15+/-0.12 vs. 0.02+/-0.11 mg/dL, p<0.001). Changes in creatinine levels were only associated with fenofibrate therapy (r=0.52, p<0.001) in the stepwise linear regression analysis.
CONCLUSION
Fenofibrate therapy for 1-3 years significantly increased creatinine levels in hypertensive patients with hypertriglyceridemia. This finding suggests that follow-up measurement of creatinine level is necessary with fenofibrate therapy.

Keyword

Fenofibrate; Creatinine; Hypertension; Hypertriglyceridemia

MeSH Terms

Creatinine
Fenofibrate
Follow-Up Studies
Humans
Hypertension
Hypertriglyceridemia
Linear Models
Retrospective Studies
Creatinine
Fenofibrate

Figure

  • Fig. 1 Changes of creatinine levels in control (A) and fenofibrate groups (B)


Cited by  1 articles

Management of Hypertriglyceridemia for Prevention of Cardiovascular Diseases
Chee Jeong Kim
J Lipid Atheroscler. 2013;2(2):53-60.    doi: 10.12997/jla.2013.2.2.53.


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