Korean Circ J.  1991 Apr;21(2):337-341. 10.4070/kcj.1991.21.2.337.

Hypotensive Effect of Perindopril in Patients with Essential Hypertension

• Bae JH
• Kang HS
• Kim KS
• Kim MS
• Song JS

• KMID: 2093280
• DOI: http://doi.org/10.4070/kcj.1991.21.2.337

Abstract

To evaluate the effect of Perindopril in patients with essential hypertension, we administered Perindopril 4 to 8mg/day once daily to 30 patients(18 males, 12 females) for 12 weeks. Baseline blood pressure after 4 weeks with placebo was 150.4+/-7.5/102.0+/-4.3mmHg. The blood pressures of the patients were declined significantly at 4th(140.6+/-14.9/95.4+/-6.5), 8th(136.7+/-11.4/91.7+/-7.6), and 12th(132.3+/-11.1/87.5+/-6.9) week(p<0.01) without change of heart rate. The blood pressure of the patients was normalized below 140/30mmHg in 24 patients(80%) and declined diastolic blood pressure more than 10mmHg in one patients. Therefore the response rate of perindopril was 83.3%. There were reported 3 patients who revealed mild adverse reactions as follows; cough, indigestion, dizziness in one each. In conclusion, these results indicate that antihypertensive therapy with perindopril single daily dose was effective in patients with mild to moderate essential hypertension and well tolerated.

Keyword

Hypertension; Perindopril

MeSH Terms

Blood Pressure
Cough
Dizziness
Dyspepsia
Heart Rate
Humans
Hypertension*
Male
Perindopril*
Perindopril