Korean J Anat.  2005 Oct;38(5):461-468.

Transplantation of Human Adipose-derived Stromal Cells Promotes Functional Recovery of Rat Spinal Cord Injury

• Lee TH

Abstract

Recovery in central nervous system (CNS) disorders is hindered by the limited ability of the system to regenerate lost cells, replace damaged myelin, and re-establish functional neural connections. Cell transplants are being actively researched for treatment of CNS injuries. This study was undertaken to examine the effects of transplanted human adipose-derived stromal cells (hADSC) on spinal cord injuries in rats. The spinal cord injuries were produced by compressing T9-10 with an aneurysm clip. The transplants were made on the seventh day after the injuries. The Basso, Beattie, and Bresnahan (BBB) scores were higher, and cavity volumes were smaller in the transplant group than they were for the non-transplant group. Immunohistochemical study revealed that the transplanted hADSC infiltrated into the injured areas of the spinal cord, but the transplanted hADSC were not differentiated into glial cells. Considering that hADSC can be used for autologous transplant, the results of the present study suggest that the transplant of hADSC may be used for the treatment of spinal cord injuries.

Keyword

CNS (central nervous system); HADSC (human adipose-derived stromal cell); Spinal cord injury; Cell transplant

MeSH Terms

Aneurysm
Animals
Autografts
Central Nervous System
Humans*
Myelin Sheath
Neuroglia
Rats*
Spinal Cord Injuries*
Spinal Cord*
Stromal Cells*
Transplants