Korean J Anat.  1999 Oct;32(5):629-635.

Detection of hepatitis B virus DNA and sister chromatid exchange in peripheral bloods from patients with chronic hepatitis B

Affiliations
  • 1Department of Anatomy, School of Medicine, Keimyung University, Taegu, Korea.

Abstract

In the present study author investigated 48 patients with chronic hepatitis B for the presence of peripheral blood HBV-DNA with the aid of DNA molecular techniques. HBV-DNA was detected in peripheral blood cells in 34 of 48 (70.8%) of chronic HBsAg positive patients. In order to know that the presence of HBV-DNA in peripheral blood induce more chromosomal instability in comparison with the absent, frequency of SCE was analyzed in peripheral blood. In HBV-DNA positive chronic hepatitis B patients a mean frequency of SCE was 11.5452+/-0.6944, in HBV-DNA negative patients 11.7540+/-0.7032, respectively. Both groups had significantly higher SCE frequence than that of normal control group (5.8533+/-0.437) (p<0.05). There was no significant difference between them. This study may suggest that the presence of HBV-DNA in peripheral blood of patients with chronic hepatitis B may be related to certain pathogenetic processes in HBV infection, but it may have no effect on chromosomal instability in peripheral blood.

Keyword

Sister chromatid exchange; Hepatitis B virus DNA; Peripheral blood

MeSH Terms

Blood Cells
Chromosomal Instability
DNA
Hepatitis B Surface Antigens
Hepatitis B virus*
Hepatitis B*
Hepatitis B, Chronic*
Hepatitis*
Hepatitis, Chronic*
Humans
Siblings*
Sister Chromatid Exchange*
DNA
Hepatitis B Surface Antigens
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