Korean J Anesthesiol.  2011 Nov;61(5):435-438. 10.4097/kjae.2011.61.5.435.

Hypotension in patients administered indigo carmine containing impurities: A case report

Affiliations
  • 1Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. kdhahm@gmail.com

Abstract

Indigo carmine has been used for eight decades with few adverse effects. Several of our patients, however, experienced severe hypotensive episodes after indigo carmine administration within a period of one month. Analysis of the raw materials used to formulate the preparation of indigo carmine we used showed that they contained impurities. Following recall of these impure materials, none of our patients experienced further hypotensive episodes.

Keyword

Adverse reaction; Hypotension; Impurity; Indigo carmine

MeSH Terms

Humans
Hypotension
Indigo Carmine
Indoles
Indigo Carmine
Indoles

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