Korean J Anesthesiol.  1997 Aug;33(2):324-329. 10.4097/kjae.1997.33.2.324.

Comparison of Sodium Nitroprusside and Esmolol Induced Hypotension for Total Hip Arthroplasty

• Eun HH
• Hwang HY
• Ryu HH
• Lee YW
• Baik SW

• KMID: 2091135
• DOI: http://doi.org/10.4097/kjae.1997.33.2.324

Abstract

BACKGROUND: Esmolol is a short acting sympathetic beta receptor antagonist, and it was successfully applied to induced hypotension. Esmolol lowers blood pressure by decreasing cardiac output, and does not cause vasodilation. This property of esmolol may help to decrease bleeding during induced hypotension. In this study, we tried to elucidate the effect of esmolol on induced hypotension for total hip arthroplasty. METHOD: Twenty patients receiving total hip arthroplasty were randomly divided to two groups. Esmolol group (10 patients) received esmolol as a hypotensive agent, and sodium nitroprusside (SNP) group (10 patients) received SNP as a hypotensive agent. We measured arterial blood gas analysis, vital sign, amounts of bleeding, amounts of transfusion and administered fluid, and various laboratory findings.
RESULTS
Induced hypotension was successfully performed in either esmolol and SNP group. Heart rate increased by SNP, and decreased by esmolol. There were no statistically significant differences between the two groups in amounts of bleeding, amounts of transfusion or administered fluid, and laboratory findings. Arterial oxygen tension was relatively constant in esmolol group, but decreased in SNP group.
CONCLUSION
Esmolol can be used as a single hypotensive agent during induced hypotension without significant side effects during total hip arthroplasty.

Keyword

Anesthetic techniques, induced hypotension; Pharmacology, esmolol, sodium ni troprusside; Surgery, orthopedic, total hip arthroplasty

MeSH Terms

Arthroplasty, Replacement, Hip*
Blood Gas Analysis
Blood Pressure
Cardiac Output
Heart Rate
Hemorrhage
Humans
Hypotension*
Nitroprusside*
Oxygen
Sodium*
Vasodilation
Vital Signs
Nitroprusside
Oxygen
Sodium