Korean J Anesthesiol.  1997 Aug;33(2):262-266. 10.4097/kjae.1997.33.2.262.

Effect of Speed of Injection on Vital Signs, Dose Requirement and Induction Time for Induction of Anesthesia using Propofol

• Yang JH
• Lee SJ
• Kil HY
• Lee SW
• Yoon YJ

• KMID: 2091126
• DOI: http://doi.org/10.4097/kjae.1997.33.2.262

Abstract

BACKGROUND: Induction of anesthesia with propofol commonly associated with reduction in systemic arterial pressure, especially in elderly and high risk patients. This reduction is influenced by the dose and rate of propofol injection. The aim of this study was to examine the effect of different injection rate of propofol on vital signs, dose requirement and induction time during induction period.
METHODS
Unpremedicated one hundred and twenty ASA physical status I and II patients aged 20~60 years scheduled for elective surgery were randomly allocated into one of four (150, 300, 600, 1200 ml/hr) groups according to speed of injection of propofol during induction period. Loss of verbal contact was taken as the end-point of induction. Vital signs, SpO2, dose requirement of propofol and induction time were checked.
RESULTS
As the injection rate of propofol became slower, there were significant reduction in induction dose and increase in induction time (p<0.05). For example, induction dose and time were 1.82 mg/kg, 223 +/- 58 sec in 150 ml/hr group and 3.14 mg/kg, 50 +/- 11 sec in 1200 ml/hr group, respectively. Also, decrease in systolic and diastolic pressure were less marked at lower injection rates.
CONCLUSIONS
Slower injection of propofol produces less vital sign changes and dose requirement for the induction of anesthesia.

Keyword

Anesthetics, intravenous, propofol; Anesthetic technique, induction

MeSH Terms

Aged
Anesthesia*
Arterial Pressure
Blood Pressure
Humans
Propofol*
Vital Signs*
Propofol