A Comparison of the Cardiovascular Response with Various Administration Method of Lidocaine during Tracheal Intubation

Yu, Byung Sik

Abstract

The purpose of this study was to compare the cardiovascular changes with various administration method of lidocaine. This study was performed 40 patients scheduled for elective surgery at chosun university hospitaL Patients were randomly assigned to recieve lidocaine by intravenous, larynogotracheal spray, transtracheal injection before tracheal intubation. Systolic blood pressure(SBP), diastolic blood pressure(DBP) mean arterial pressure(MAP) and Heart rate(HR) were measured at preinduction and 1, 2, 3, & 5 minutes after intubation. The results were as follows; 1) Control group; not administered lidocaine; SBP, DBP, MAP % HR were significantly increased at 1, 2 minutes after intubation(P<0.05, P<0.01). 2) Group 1; intravenous lidocaine administration(2 mg/kg);, SBP, DBP, MAP were increased but not statistically significant. Heart rate was significantly increased at 1, 2, 3 minutes after intubation(P<0.05, P<0.01). Compared with control group, SBP, DBP & MAP were statistically significant (P<0.05). 3) Group 2; laryngotracheal spray(2 mg/kg); Similar to group 1 but DBP was increased at 1 minute after intubation(P<0.05). and SBP, DBP, MAP & HR were maintained higher level than group I at every time. 4) Group 3; Transtracheal injection of l% lidocaine 2~3 ml; SBP, DBP & MAP were not exceed baseline level at 1 minute but HR was significantly increased at l, 2 minutes after intuhation(P<0.05). Compared with control group, SBP, DBP, and MAP were statistically singnificant (P<0.05). This study suggest that administration of lidocaine attenuate sympathetic stimulation follwing tracheal intubation. Intravenous injection of lidocaine is recommendable method to prevent the sympathetic stimulation following tracheal intubation.