Korean J Asthma Allergy Clin Immunol.
2004 Jun;24(2):236-240.
Association of beta2-adrenoceptor Polymorphisms with Baseline FEV1 in Asthmatics
Abstract
- BACKGROUND
It has been well known that beta2-adrenergic receptor (beta2-AR) is involved in the regulation of airway tone and is related to the development of asthma related phenotypes. The beta2-AR gene polymorphisms have been associated with the parameter of lung function test, but this genetic determinant remains unclear.
OBJECTIVE
The aim of this study was to determine whether two polymorphisms at codon 16 and 27 of beta2-AR gene are associated with the parameters of pulmonary function test in asthmatics. METHODS: We genotyped 148 adult asthmatics who were newly diagnosed without taking any prescription. PCR-based methods were used to determine the haplotype of 2 polymorphisms (codon 16 and 27) within beta2-AR gene. Spirometry was performed before administration of bronchodilator. RESULT: The Gly16-Glu27 genotype was significantly associated with higher FEV1 as only qualitative (<80% of predicted value) phenotype (P=0.044). However, no significant association was found between haplotype of beta2-AR gene and FVC. CONCLUSION: These results suggest that variation in beta2-AR gene or a nearby gene may be associated with protective effect of bronchoconstriction in asthma patients.
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