Cutaneous Manifestations in End-stage Renal Disease on Hemodialysis and Peritoneal Dialysis

Choi, Seung Il; Lee, Jong Suk; Lee, Sung Yul; Lee, Eun Young

Abstract

BACKGROUND
End-stage renal disease (ESRD) is accompanied by various skin manifestations, and recently, the survival time of patients is increasing owing to the development of dialysis treatment, and skin manifestations are on the rise.
OBJECTIVE
The objective of this study is to investigate the differences in skin changes, according to the dialysis method and period in ESRD patients, and to verify whether a correlation exists between the factors that affect pruritus.
METHODS
Various kinds of skin manifestations were identified by examining and asking 80 outpatients detailed questions and the difference was examined by classifying them into groups, according to the dialysis method and period.
RESULTS
The most common symptoms were xerosis (91%) and pruritus (85%). The study showed that most symptoms occurred more frequently in the peritoneal dialysis group than the hemodialysis, and among these, the change of sweating had a significant difference (p=0.043). As the dialysis period got longer, skin manifestation generally showed a higher frequency, and the particular bleeding tendencies and nail abnormalities showed an obvious difference. Results considering the relation of severity of pruritus and xerosis with the dialysis method and period showed a significant increase only in pruritus, according to the dialysis period (p=0.003).
CONCLUSION
Skin changes showed a high frequency in peritoneal dialysis, but it didn't show a significant difference. Bleeding tendencies, changes of sweating, and nail abnormalities, according to the dialysis period, showed a significant difference. Factors causing pruritus were more related with xerosis than blood levels showing a renal function.