Korean J Dermatol.
2003 Jul;41(7):965-967.
A Case of Cutaneous Manifestations Associated With Hydroxyurea Therapy
- Affiliations
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- 1Department of Dermatology, Presbyterian Medical Center, Chonju, Korea. drsuejin@hanmail.net
Abstract
- Hydroxyurea is an antitumor agent that has attained an important role in the management of myeloproliferative syndromes. Its mechanism of action is not fully understood, but it appears to affect DNA synthesis and genetic control of cell replication by inhibiting the conversion of ribonucleotides in deoxyribonucleotides. Cutaneous side effects such as xerosis, hyperpigmentation, nail changes, skin ulceration, alopecia, and palmoplantar keratoderma may occur, especially with long-term treatment. We report a case of 65-year-old chronic myelogenous leukemia(CML) patient showing various cutaneous manifestations after receiving long-term hydroxyurea therapy.
