Korean J Dermatol.  2001 Aug;39(8):935-937.

A Case of Type V Hyperlipoproteinemia with Xanthoma Eruptivum

• Lee SY
• Lee WS
• Chang SE
• Choi JH
• Sung KJ
• Moon KC
• Koh JK

Abstract

We report a case of type V hyperlipoproteinemia with xanthoma eruptivum associated with diabetes mellitus. An 18-year-old female patient presented with multiple, erythematous papules on the trunk, buttocks, and both extremities and multiple orange-yellow colored, conglomerated nodules on the elbows and knees. Laboratory examination showed increased serum blood glucose, cholesterol and triglyceride. Lipoprotein electrophoresis showed increased pre-beta and chylomicron bands. Analysis of lipoprotein revealed increase of very low density lipoprotein (VLDL) and triglyceride levels in the plasma. A skin biopsy from the papule on the trunk revealed a xanthoma. We diagnosed the patient as type V hyperlipoproteinemia. After 10 months of treatment with insulin and gemfibrozil, the serum levels of cholesterol and triglyceride were reduced to normal level. The skin lesions showed marked improvement without scar.

Keyword

Type V hyperlipoproteinemia; Xanthoma eruptivum

MeSH Terms

Adolescent
Biopsy
Blood Glucose
Buttocks
Cholesterol
Cicatrix
Diabetes Mellitus
Elbow
Electrophoresis
Extremities
Female
Gemfibrozil
Humans
Hyperlipoproteinemia Type V*
Insulin
Knee
Lipoproteins
Plasma
Skin
Triglycerides
Xanthomatosis*
Blood Glucose
Cholesterol
Gemfibrozil
Insulin
Lipoproteins