Korean J Dermatol.  1996 Aug;34(4):697-702.

A Case of type IV Hyperlipoproteinemia with Xanthoma tuberosum and Xanthoma Eruptivum

• Jung JW
• Lee SC
• Won YH
• Chun IK

Abstract

We report a case of type IV hyperlipoproteinemia associated with xanthoma tuberosum and xanthoma eruptivum, which improved by treatment with gernfibrozil and procetofene. A 46-year-old male patient visited our clinic for evaluation of multiple orange-yellow colored nodules on the elbows and multiple papules on the knees, buttocks and back. Laboratory examination showed an abnormal elevation of serun cholesterol and triglyceride. Lipoprotein electrophoresis showed an increase of pre-b band and plasma standing test showed turbid plasma. Analysis of lipoprotein revealed increase of VLDL level in his plasma. The biopsy specimens from the nodule on the elbow and the papule on the back revealed characteristic findings of xanthoma. We diagnosed the patient as type IV hyperlipoproteinemia. After 5 months of treatment with diet restriction, gemfibrozil, and procetofene, the serum levels of cholesterol and triglyceride were reduced to normal level. The skin lesions of the both back and buttock showed marked improvement and the skin lesions on the elbows and knee were much improved.

Keyword

Type IV hyperlipoproteinemia; Xanthoma eruptivum; Xanthoma tuberosum

MeSH Terms

Biopsy
Buttocks
Cholesterol
Diet
Elbow
Electrophoresis
Fenofibrate
Gemfibrozil
Humans
Hyperlipoproteinemia Type IV*
Knee
Lipoproteins
Male
Middle Aged
Plasma
Skin
Triglycerides
Xanthomatosis*
Cholesterol
Fenofibrate
Gemfibrozil
Lipoproteins