Korean J Dermatol.  2001 Jun;39(6):703-706.

A Case of Subcutaneous Panniculitic T-cell Lymphoma

• Park JH
• Kim JO
• Park JH
• Ryoo YW
• Kim BC
• Lee KS

Abstract

Subcutaneous panniculitic T-cell lymphoma(SPTCL) is a rare subtype of peripheral T-cell lymphoma that clinically and histologically mimics benign panniculitis. It represents subcutaneous nodules predominatly on extremities and trunk and hemophagocytic syndrome almost leading to death. A 29-year-old women presented with multiple tender subcutaneous nodules on lower abdomen and extremities for 6 months often with fevers and chills. There was no hepatosplenomegaly or lymphadenopathy. Skin biopsy specimen showed dense diffuse infiltration of atypical lymphocytes in the subcutis, with extensive fat necrosis and karyorrhexis. The immunophenotypic studies showed a cytoxic T-lymphocyte profile, i.e., LCA+, UCHL+, CD8+, CD20-, CD30-, and CD56-. In immunohistochemical studies for the Ebstein-Barr virus resulted in a negative finding. On the basis of the clinical and histological finding, we established the diagnosis of SPTCL.

Keyword

Subcutaneous panniculitic T-cell lymphoma; Hemophagocytic syndrome

MeSH Terms

Abdomen
Adult
Biopsy
Chills
Diagnosis
Extremities
Fat Necrosis
Female
Fever
Humans
Lymphatic Diseases
Lymphocytes
Lymphohistiocytosis, Hemophagocytic
Lymphoma, T-Cell*
Lymphoma, T-Cell, Peripheral
Panniculitis
Skin
T-Lymphocytes*