Korean J Dermatol.
1999 Dec;37(12):1823-1826.
Subcutaneous Panniculitic Angiocentric T/NK-Cell Lymphoma
- Affiliations
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- 1Department of Dermatology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.
- 2Department of Pathology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.
- 3Department of Samsung Masan Hospital, Korea.
Abstract
- Nasal-type T/NK cell lymphoma shows frequent extra-nodal involvement including skin with poor prognosis. Subcutaneous panniculitic T-cell lymphoma which is characterized by subcutaneous nodules, systemic signs and symptoms, and a hemophagocytic syndromes was also identified and must be differentiated with primary cutaneous nasal-type T/NK cell lymphoma. We report a case of subcutaneous angiocentric T/NK cell lymphoma in a 77-year-old man who had multiple deep ulcers on the extremities. Strong CD56 positivity and EBV RNA by in situ hybridization were demonstrated in the angiocentric infiltrates of the subcutis. The skin lesions were resistant to combination chemotherapy and pancreatic involvement of lymphoma developed. One year after onset of the skin lesions, he had a rapid downhill course.
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