Korean J Med.
2015 Mar;88(3):313-317. 10.3904/kjm.2015.88.3.313.
A Case of Massive Levothyroxine Intoxication in a Patient with Total Thyroidectomy
- Affiliations
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- 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Chosun University Hospital, School of Medicine, Chosun University, Gwangju, Korea. endocrine@chosun.ac.kr
- KMID: 2082593
- DOI: http://doi.org/10.3904/kjm.2015.88.3.313
Abstract
- The use of levothyroxine is increasingly widespread. There are relatively few reports of acute massive levothyroxine intoxication leading to emergencies in adults, and such intoxication has a wide range of presentations. Although thyroid gland activity is suppressed by thyroid stimulating hormone as a result of overdose exposure to exogenous thyroid hormone, it is unclear what symptoms are to be expected in acute levothyroxine intoxication in the absence of the thyroid gland. We report a case of massive acute levothyroxine intoxication in a patient with total thyroidectomy, along with observed changes over time in thyroid hormone levels and symptoms. To the best of our knowledge, this report presents the first description of acute massive levothyroxine intoxication in the absence of a thyroid gland.
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