Korean J Med.  2005 Feb;68(2):215-219.

A case of primary pulmonary NK-cell lymphoma

• Lee JH
• Huh J
• Kim SW
• Ko OB
• Youn SM
• Kang YK
• Suh C

Abstract

NK-cell lymphoma, distinct clinicopathologic entity, almost always occurs in the naso-sinal region. NK-cell lymphomas of other extranodal sites have also been recognized in previous case reports, but very rare. As far as we know, only four cases of primary pulmonary NK-cell lymphoma were reported worldwide. We experienced a case of primary pulmonary NK-cell lymphoma. A 54-year-old man was admitted because of cough and chest discomfort. The chest CT shows multifocal ground-glass and nodular opacities in both lungs. Video Assisted Thoracoscopy (VATS) was performed to assess the lung lesion. The tumor cells were characterized by cytoplasmic CD3 (+), CD56 (+), T-cell receptor antigen (-), Epstein-Barr Virus (+) and T-cell gene rearrangement (-), These findings were compatible with NK-cell lymphoma. So we performed the whole body Flurodeoxyglucose-Positron Emission Tomography (FDG-PET) to exclude any other lesion. The FDG-PET showed multiple hypermetabolic lesions only located in both lungs. The patient underwent 6 cycles of chemotherapy according to a CHOP regimen. Now his disease state is complete remission. To our knowledge, this is the first case of primary pulmonary NK-cell lymphoma in Korea.

Keyword

NK-cell lymphoma; Primary pulmonary

MeSH Terms

Cough
Cytoplasm
Drug Therapy
Gene Rearrangement, T-Lymphocyte
Herpesvirus 4, Human
Humans
Korea
Lung
Lymphoma*
Middle Aged
Receptors, Antigen, T-Cell
Thoracoscopy
Thorax
Tomography, X-Ray Computed
Receptors, Antigen, T-Cell