Prevalence of early renal damage between dippers and non-dippers in mild to moderate Korean hypertensives

Park, In soo

Abstract

BACKGROUND
Non-dipper hypertension is defined as an improper nocturnal blood pressure falling less than 10/5 mmgHg or 10% in systolic and diastolic. Clinical studies have shown that target organ damages tend to be more frequent in non-dipper hypertensives. Author tried to elucidate whether non-dippers in untreated mild to moderate hypertension has more evidence of early renal damage or not.
METHODS
Total 141 untreated mild to moderate Korean essential hypertensives including borderline hypertensives and 47 controls were subjected. Diabetes, chronic renal failure, heart failure, severe hypertension (above stage-III by JNC-VI criteria), isolated systolic hypertension and macroproteinuric cases (UAER >200 microgram/mL/min) were excluded to profit this study purpose. Subject was defined as non-dipper when nocturnal blood pressure fall was less than 10/5 mmHg. Urine microalbumin was analyzed by radioimmunoassay, and their excretion rate was calculated according to 24 hr urine volume. All data were compared and analyzed statistically by using of SPSS package. RESULT: Prevalence of non-dipper is not different between both groups (hypertension vs control ; 21.3% vs 25.5%, p>0.05). In hypertensive group, incidence of significant UAER and mean UAER were not different between dipper and non-dipper (all p>0.05).
CONCLUSION
In this study, evidence of early renal damage in non-dipper hypertensive was not differ from dipper hypertensives. Long-term study would be necessary to observe for further renal damage in non-dipper hypertensives.