Korean J Nephrol.  2007 Jul;26(4):420-426.

Association of Metabolic Syndrome in Non-diabetic and Non-hypertensive Adults with Increased Risk for Chronic Kidney Disease

• Choi SY
• Lee JE
• Do YS
• Jang EH
• Kim YK
• Huh W
• Kim YG
• Kim DJ
• Oh HY

Abstract

PURPOSE: The significance of metabolic syndrome (MS) was recently raised as a risk factor in chronic kidney disease (CKD). Diabetes and hypertension are not only well known diagnostic criteria for MS, but also risk factors for CKD. However, the association between MS and CKD in patients without diabetes and hypertension is unknown.
METHODS
A total of 9586 subjects who registered in the health check service at Samsung Medical Center between January 2004 and December 2005 were included. MS was defined according to the criteria of the revised ATP III, and CKD was defined by the reduction of the glomerular filtration rate or the appearance of albuminuria.
RESULTS
The prevalence of MS was 9.0% of study subjects. CKD was noticed in 6.2% of the subjects without MS, and 13.1% with MS. MS was a significant determinant of CKD {Odd ratio (OR) 1.80 and 95% confidence interval (CI) 1.42-2.28, p<0.001}. Compared with subjects lacking components of MS, subjects with one, two, three, four or five components of MS had a higher risk of acquiring CKD (OR, 1.04, 1.43, 1.89, 2.48, 3.29, Respectably). The relationship between each component of MS and CKD was different according to sex and age groups. Abdominal obesity was a significant determinant for CKD in female subjects, while high fasting glucose levels were a significant determinant in younger subjects (<60 years) (p<0.05).
CONCLUSION
Even in non-diabetic and non-hypertensive adults, MS is independently associated as a risk factor for CKD.

Keyword

Metabolic syndrome X; Renal insufficiency; Chronic

MeSH Terms

Adenosine Triphosphate
Adult*
Albuminuria
Fasting
Female
Glomerular Filtration Rate
Glucose
Humans
Hypertension
Metabolic Syndrome X
Obesity, Abdominal
Prevalence
Renal Insufficiency
Renal Insufficiency, Chronic*
Risk Factors
Adenosine Triphosphate
Glucose