J Korean Soc Hypertens.  2011 Sep;17(3):125-132. 10.5646/jksh.2011.17.3.125.

Influence of Metabolic Syndrome on Hypertension-related Target Organ Damage: Diagnosis of Metabolic Syndrome Is Still Necessary

• Lee SR
• Kim DJ
• Sung KC
• Cho EJ
• Hyun MS
• Park JB
• Kim YK
• Lee IK
• Kim CH
• Lee HY

• KMID: 1750394
• DOI: http://doi.org/10.5646/jksh.2011.17.3.125

Abstract

BACKGROUND
The value of metabolic syndrome (MetS) evaluation in predicting cardiovascular disease is recently criticized. We investigated, in hypertensive patients without diabetes mellitus, the influence of MetS on the target organ damage.
METHODS
Data from the fourth Korean National Health and Nutrition Examination Survey performed in 2008 were analyzed. Metabolic syndrome is defined by the 2001 National Cholesterol Education Program-Third Adult Treatment Panel guideline. The category of hypertension is defined following the seventh report of the Joint National Commitee-7 guideline.
RESULTS
The prevalence of target organ damage (TOD), defined as history of myocardial infarction/angina/stroke/chronic renal disease as well as the presence of macroalbuminuria, was increased according to blood pressure; 8.5% in the population of normal blood pressure, 12.5% in those of prehypertensive range, and 20.5% in hypertensive population. Hypertensive population associated with MetS showed greater prevalence of TOD than those without MetS even excluding diabetic population. The presence of MetS in hypertensive population showed 2.2 fold increased risk for TOD. Any single parameter of MetS diagnostic criteria as well as obesity did not show the comparable range of risk prediction as MetS.
CONCLUSIONS
These results indicate a strong relationship of Mets with TOD in hypertensive population. Evaluating the metabolic components in hypertensive population is necessary in establishing management strategies for overall risk.

Keyword

Hypertension; Metabolic syndrome; Target organ damage

MeSH Terms

Adult
Blood Pressure
Cardiovascular Diseases
Cholesterol
Diabetes Mellitus
Humans
Hypertension
Joints
Nutrition Surveys
Obesity
Prevalence
Cholesterol

Figure

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  Fig. 1. Prevalence of target organ damage according to blood pressure category. TOD, target organ damage; CAD, Coronary artery disease.

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  Fig. 2. The prevalence of target organ damage according to co-morbid cardiovascular risk factor in hypertensive population. IFG, Impaired fasting glucose.

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  Fig. 3. Area under curve of each diagnostic criteria of metabolic syndrome from receiver-operating characteristic analysis in Korean hypertensive population with metabolic syndrome. BMI, body mass index; Low HDL, low high density lipoproteinemia; High TG, high triglyceridemia; MetS, metabolic syndrome.

Reference

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