Korean J Nephrol.  2003 Sep;22(5):597-601.

A Case of Acute Myocardial Infarction Due to Coronary Artery Thrombosis During the Relapse of Nephrotic Syndrome

• Paik EK
• Park JW
• Kim YN
• Moon IS
• Lee HH
• Lee JS
• Chung WK
• Shin EK
• Park MH
• Lee JH

Abstract

Vascular thrombosis is one of the most serious complications in patients with nephrotic syndrome, but thrombosis occurs mainly in venous system. Arterial thrombosis is much less common and coronary artery thrombosis is rarely reported worldwide. We experienced a case of an acute myocardial infarction due to coronary artery thrombosis in a young male with minimal change disease during nephrotic relapse. This 35 year-old male was diagnosed to have minimal change nephrotic syndrome 15 years before admission. Two days before admission, he was found to have heavy proteinuria and edema which led to impression of relapse of nephrotic syndrome. Acute myocardial infarction was developed one day before admission and emergency thrombolytic therapy was performed. After admission, coronary angiography was performed and multiple thrombi were identified in distal left anterior descending artery without marked atherosclerotic changes. The formation of intracoronary thrombi in this patient appeared to be due to the hypercoagulable state associated with the relapse of nephrotic syndrome.

Keyword

Nephrotic syndrome; Acute myocardial infarction; Intracoronary thrombosis; Hypercoagulable state

MeSH Terms

Adult
Arteries
Coronary Angiography
Coronary Vessels*
Edema
Emergencies
Humans
Male
Myocardial Infarction*
Nephrosis, Lipoid
Nephrotic Syndrome*
Proteinuria
Recurrence*
Thrombolytic Therapy
Thrombosis*