Prospective Analysis of Factors that Affect Change of Lipoprotein(a) in Hemodialysis Patients During 2 Years

Kim, Gyeong A; Song, Joon Ho; Lee, Kyong Ju; Park, Young Ju; Lee, Seoung Woo; Kim, Moon Jae

Abstract

Lipoprotein(a) [Lp(a)] is an independent risk factor for cardiovascular disease that is a major cause of death in dialysis patients. It has been described to be increased in chronic renal failure patients on conservative treatment or dialysis. It has also been suggested that high concentration of Lp(a) correlates to malnutrition of hemodialysis patients, but this has unproven. The aim of our study was the evaluation of factors that affect changes of Lp(a) concentration through follow up in hemodialysis patients. We assessed the serum concentrations of lipoprotein(a), serum albumin, nPCR, various biochemical parameters and Kt/V as adequacy of dialysis in 25 hemodialysis patients over a 48-months period. The mean serum concentrations of Lp(a) were 40.0+/-21.3mg/dL at basal level, 39.2+/-16.6mg/dL after 48 months, respectively. Significant correlation was found between basal and follow up Lp(a) levels(r=0.76, p=0.0001). Moreover, a significant inverse correlation was observed between changes of serum Lp(a) level and changes of serum albumin level(r=-0.507, p=0.027). However no significant correlation was found between changes of serum Lp(a) level and changes of lipid profiles, nPCR, URR and Kt/V. Our data suggests the possibility of the influence of nutritional status(changes of serum albumin) on changes of serum Lp(a) level in hemodialysis patients. Further prospective studies are warranted to clarify the influence of nutritional status on the Lp(a) in hemodialysis patients.