Ewha Med J.  1995 Dec;18(4):523-527. 10.12771/emj.1995.18.4.523.

A Case of Adult Polycystic Kidney Disease Presinted with Nephrotic Syndrome

• Jung HK
• Shin MS
• Kang DH
• Choi GB
• Youn KI

• KMID: 2078853
• DOI: http://doi.org/10.12771/emj.1995.18.4.523

Abstract

OBJECT: The adult polycystic kidney disease(APCK) is inheritant disease in which cysts aredistributed throught the cortex and medulla of both kidneys. The disease process is usually notclinically apparent until the third or fourh decade of life. Mild persistent proteinuria(> 200mg/d) can be developed in 20% to 40% of cases, but nephrotic-range proteinuria is rare and whenfound, should prompt a search for the other concomitant renal disorder, such as IgA nephropathy, rapidly progressive glomerulonephropathy, focal glomerulosclerosis. MATERIAL AND RESULT: We report a case of APCK presented with nephrotic syndrome. A 76-year-old man was admitted due to generalized edema with weakness. The blood pressure was120/80mmHg. The BUN/creatinine were 15/1.2mg/dl, serum albumin 2.9g/dl, cholesterol / triglyceride 432/273mg/dl, total urinary protein excretion 8.41g/day. The serum level of IgG, IgAS, IgM, C3, C4 were within normal range and anti-nuclear antibody and anti-double strand DNA antibody were also negative. The abdominal ultrasonography and computerized tomography revealed multiple large cysts in both kidneys.The patient was treated with Enalapril(R), an angiotensin converting enzyme inhibitors, 5mg forcontrol of proteinuria.
CONCLUSION
The APCK presented with nephrotic syndrome is rare and to our knowledge,this is a first report in Korea.

Keyword

APCK; Proteinuria; Nephrotic syndrome

MeSH Terms

Adult*
Aged
Angiotensin-Converting Enzyme Inhibitors
Blood Pressure
Cholesterol
DNA
Edema
Enalapril
Glomerulonephritis, IGA
Glomerulosclerosis, Focal Segmental
Humans
Immunoglobulin A
Immunoglobulin G
Immunoglobulin M
Kidney
Korea
Nephrotic Syndrome*
Polycystic Kidney Diseases
Polycystic Kidney, Autosomal Dominant*
Proteinuria
Reference Values
Serum Albumin
Triglycerides
Ultrasonography
Angiotensin-Converting Enzyme Inhibitors
Cholesterol
DNA
Enalapril
Immunoglobulin A
Immunoglobulin G
Immunoglobulin M
Serum Albumin