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The role of calmodulin in regulating calcium-permeable PKD2L1 channel activity

Park EY, Baik JY, Kwak M, So I

Polycystic kidney disease 2-like-1 (PKD2L1), polycystin-L or transient receptor potential polycystin 3 (TRPP3) is a TRP superfamily member. It is a calcium-permeable non-selective cation channel that regulates intracellular calcium concentration...
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Basiliximab-Induced Non-Cardiogenic Pulmonary Edema in a Kidney Transplant Patient

Lee YJ, Park BS, Park S, Park KM, Park JH, Park IH, Kim YW

Induction therapy with basiliximab is widely administered after kidney transplantation to prevent acute rejection. Herein, we report a case of non-cardiogenic pulmonary edema induced by basiliximab. To the best of...
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Predictors and outcomes of laparoscopic nephrectomy in autosomal dominant polycystic kidney disease

Chen K, Tan YG, Tan D, Pek G, Huang HH, Sim SP

PURPOSE: Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease, and 20% of patients eventually require nephrectomies due to compressive symptoms or renal-related complications. Traditionally, nephrectomies...
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Femoral Neuropathy Secondary to Autosomal Dominant Polycystic Kidney Disease: A Case Report

Yoo J, Lim KB, Lee HJ, Kim J, You EC, Kang J

Compressive femoral neuropathy is a disabling condition accompanied by difficulty in hip flexion and knee extension. It may result from retroperitoneal hematoma or bleeding, or from complications associated with pelvic,...
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Incidental Detection of Peri-Renal Hemorrhage on F-18 FDG PET/CT Imaging in a Patient with Polycystic Kidney Disease

Kim MH, Kim DW

A 72-year-old male patient with a history of polycystic kidney disease and lung malignancy underwent F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) for the evaluation of tumor recurrence. The...
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Autosomal Dominant Polycystic Kidney Desease Coexisting with Renal Dysplasia. First Case Described and Followed Since Prenatal Period

Truyols C

Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent hereditary renal disease and causes terminal chronic renal failure. ADPKD is characterized by bilateral multiple renal cysts, which are produced...
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Focal segmental glomerulosclerosis in atypical polycystic kidney disease

Bae EH, Kim H, Kim SS, Ma SK, Kim SW

No abstract available.
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Mitogen-activated Protein Kinases in the Development of Normal and Diseased Kidneys

Awazu M

Mitogen-activated protein kinases (MAPKs) play important roles in various cellular functions including proliferation, differentiation, and apoptosis. We showed that MAPKs are developmentally regulated in the rat kidney. p38 MAPK (p38)...
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Baseline Cardiovascular Characteristics of Adult Patients with Chronic Kidney Disease from the KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD)

Kim H, Yoo TH, Choi KH, Oh KH, Lee J, Kim SW, Kim TH, Sung S, Han SH, KNOW-CKD Group

Cardiovascular disease (CVD) is the most common cause of death in patients with chronic kidney disease (CKD). We report the baseline cardiovascular characteristics of 2,238 participants by using the data...
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Baseline General Characteristics of the Korean Chronic Kidney Disease: Report from the KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD)

Kang E, Han M, Kim H, Park SK, Lee J, Hyun YY, Kim YS, Chung W, Kim HJ, Oh YK, Ahn C, Oh KH

The KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD) was developed to investigate various clinical courses and risk factors for progression of Korean chronic kidney disease...
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Two cases of TSC2/PKD1 contiguous gene deletion syndrome

You J, Kang E, Kim Y, Lee BH, Ko TS, Kim GH, Choi JH, Yoo HW

Tuberous sclerosis complex (TSC, MIM#191100) is an autosomal dominant neurocutaneous syndrome caused by mutation or deletion of TSC1 encoding hamartin or TSC2 encoding tuberin and characterized by seizure, mental retardation,...
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Diagnosis and treatment of patients with IgA nephropathy in Japan

Tomino Y

Chronic kidney disease (CKD) is a worldwide public health problem that affects millions of people from all racial and ethnic groups. Although CKD is not one specific disease, it is...
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Recent Advances in the Management of Autosomal Dominant Polycystic Kidney Disease

Park H, Hwang YH

Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease. It is characterized by the dysregulated growth of kidney cysts, resulting in end-stage kidney failure. By identifying...
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An unusual de novo duplication 10p/deletion 10q syndrome: The first case in Korea

Lee BY, Park JY, Lee YW, Oh AR, Lee SY, Choi EY, Kim MY, Ryu HM, Park SY

We herein report an analysis of a female baby with a de novo dup(10p)/del(10q) chromosomal aberration. A prenatal cytogenetic analysis was performed owing to abnormal ultrasound findings including a choroid...
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Successful Endovascular Stent-Graft Repair for Complicated Type B Aortic Dissection Developed in a Patient with Polycystic Kidney Disease

Jung CS, Park BW, Bang DW, Jang WH, Kim HS, Oh JH

Polycystic kidney disease (PCKD) is rarely associated with aortic dissection (AD), which is a life-threatening disease. Although endovascular stent-graft repair tends to show better outcomes than conventional therapies in complicated...
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Renal Artery Embolization in Patients with Polycystic Kidney Disease

Lim K, Kim JS, Lee GH, Won JH, Shin GT, Kim H, Park IW

Polycystic kidney disease (PCKD) is the most common life-threatening genetic disease that causes kidney failure worldwide. Patients with autosomal dominant PCKD notice an increase in abdominal size as the kidney...
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Newly Detected PKHD1 Gene Mutation in a Newborn with Fatal Autosomal Recessive Polycystic Kidney Disease

Byun YJ, Do HJ, Oh SH, Kim CJ, Lee BH, Kim GH, Lee BS, Kim KS, Kim AR

Autosomal recessive polycystic kidney disease is among the most common inherited ciliopathies and is caused by mutations in the polycystic kidney and hepatic disease 1 (PKHD1) gene. Despite its great...
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Severe and persistent hypotension after simultaneous nephrectomy and kidney transplantation in patients with chronic renal failure caused by polycystic kidney disease: Two cases report

Hong SH, Huh JW, Lee J

Patients with autosomal dominant polycystic kidney disease have significant morbidity due to large kidney size. Surgical extirpation of polycystic kidneys is frequently necessary to treat the morbidity or to obtain...
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Clinical Application of V2 Receptor Antagonists

Oh IH, Kim GH

  • KMID: 2269331
  • Korean J Med.
  • 2014 Jun;86(6):686-694.
Hyponatremia results from a relative excess of total body water compared with the sodium content. Except for primary polydipsia, vasopressin activation plays a major role in pathogenesis of water retention....
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Two siblings with Bardet-Biedl syndrome caused by mutations in BBS10: the first case identified in Korea

Yoon SC, Lee HJ, Ko JM, Kang HG, Cheong HI, Yu HG, Kim JH

Bardet-Biedl syndrome (BBS) is a rare ciliopathy generally inherited with an autosomal recessive pattern. BBS is characterized by 6 primary features namely retinal dystrophy, obesity, postaxial polydactyly, renal dysfunction, learning...
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