Korean J Obstet Gynecol.  2012 Aug;55(8):582-585. 10.5468/KJOG.2012.55.8.582.

Undifferentiated sarcoma arising in a mature cystic teratoma of the ovary

• Yoon HG
• Lee ES
• Kim HY

• KMID: 2078109
• DOI: http://doi.org/10.5468/KJOG.2012.55.8.582

Abstract

Malignant transformation within a mature cystic teratoma occurs in less than 2% of cases and most commonly results in a squamous cell carcinoma. Other reported malignancies include adenocarcinoma, various pure sarcomas, melanomas and basal cell carcinomas, and anaplastic carcinoma. We report a rare case of a 46-year-old woman with undifferentiated sarcoma arising in a teratoma of the ovary.

Keyword

Malignant transformation; Ovary; Sarcoma; Teratoma

MeSH Terms

Adenocarcinoma
Carcinoma
Carcinoma, Basal Cell
Carcinoma, Squamous Cell
Female
Humans
Melanoma
Middle Aged
Ovary
Sarcoma
Teratoma

Figure

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  Fig. 1 Computed tomography of the left ovarian mass showed multiseptated cyst containing fat fluid, hair and calcification with internal solid portion. Dirty infiltration is shown around the fat plane.

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  Fig. 2 The positron emission tomography study demonstrated extensive bone metastasis of left ovarian cancer.

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  Fig. 3 (A) Gross appearance of left ovary. 13 × 9 × 7 cm sized lobulated mass contained mixed solid and cystic components. (B) About a half of the mass is occupied by conglomerated hair shafts and two teeth are also seen. (C) H&E staining for ovarian sarcoma. There are mature teratoma components (×100). (D) Diffuse infiltration of pleomorphic, multinucleated giant cells without organoid pattern was observed, that means high grade undifferentiated sarcoma (×400).

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