Korean J Obstet Gynecol.  2008 Jul;51(7):744-749.

The clinical implications of acquired thrombophilia in patients with ovarian hyperstimulation syndrome

• Kim SM
• Jee BC
• Kim JW
• Youn JM
• Lee HU
• Suh CS
• Kim SH

Abstract

OBJECTIVE
To investigate the clinical significance of thrombophilia in patients admitted with ovarian hyperstimulation syndrome (OHSS).
METHODS
Twenty-five infertile women who were admitted into university hospital due to OHSS after ovarian hyperstimulation for intrauterine insemination or in vitro fertilization. Blood samples were drawn at the time of admission and three thrombophilic factors were assayed; antithrombin III, protein C and protein S. Subjects were divided into severe (n=18) and mild-to-moderate (n=7) OHSS, and laboratory parameters including three thrombophilic factors were compared.
RESULTS
Antithrombin III level was abnormal in 40% of subjects, protein C in 12%, and protein S in 72%. There was no significant difference in the laboratory parameters between the patients with normal (n=15) and abnormal antithrombin III levels (n=10). However, the patients with abnormal antithrombin III levels had significantly more severe OHSS than those with normal value (100% vs 55.6%, P=0.013). The patients with at least one abnormal thrombophilic factor had significantly more severe OHSS than those with all normal value (94.4% vs 42.9%, P=0.012).
CONCLUSIONS
Thrombophilic factors, particularly antithrombin III, may be associated with disease severity in patients with OHSS.

Keyword

Ovarian hyperstimulation syndrome; Thrombophilia; Antithrombin III

MeSH Terms

Antithrombin III
Female
Fertilization in Vitro
Humans
Insemination
Ovarian Hyperstimulation Syndrome
Protein C
Protein S
Reference Values
Thrombophilia
Antithrombin III
Protein C
Protein S