Korean J Obstet Gynecol.  2002 Nov;45(11):1897-1902.

Studies on Pregnanacy Rate of Controlled Ovarian Hyperstimulation before Intrauterine Insemination in the Treatment of Unexplained Infertility

• Ahn SH
• Lee IH
• Ko HE
• Chung KN
• Shim ES
• Koh JW
• Kim YB

Abstract

OBJECTIVE
To determine which regimen for controlled ovarian hyperstimulation is the most effective in achieving pregnancy after intrauterine insemination in the treatment of unexplained infertility.
MATERIALS AND METHODS
From March 1996 to February 2000, a total of 67 cycles of intrauterine insemination after controlled ovarian hyperstimulation were treated in 39 patients under 40 years old who diagnosed as unexplained infertility. Two methods of controlled ovarian hyperstimulation were used. The one is clomiphene citrate/hMG and the other is hMG only. These were compared the pregnancy rate respectively.
RESULTS
Mean age of study group was 32+/-2.7 years old (28-38 years old) and mean duration of infertility was 46+/-17.8 months (15-96 months). The overall clinical pregnancy rate was 17.9% (12/67 cycle) per cycle and 30.7% (12/39 patient) per patient. According to the methods of controlled ovarian hyperstimulation, pregnancy rate was 16.7% (8/48 cycle) after clomiphene citrate/hMG used, 21.1% (4/19 cycle) after hMG only used. 4 cases of ovarian hyperstimulation syndrome developed (clomiphene citrate/hMG 1 case, hMG only 3 cases) and all of them were self-regressed.
CONCLUSION
Compared with using hMG only as controlled ovarian hyperstimulation before intrauterine insemination, using clomiphene citrate/hMG was more effective regimen and considered as the first choice in the treatment of unexplained infertility.

Keyword

Unexplained infertility; controlled ovarian hyperstimulation; Intrauterine insemination

MeSH Terms

Adult
Clomiphene
Female
Humans
Infertility*
Insemination*
Ovarian Hyperstimulation Syndrome
Pregnancy
Pregnancy Rate
Clomiphene