Korean J Obstet Gynecol.  1997 Sep;40(9):1846-1857.

Prenatal Cytogenetic Diagnosis in Balanced Chromosome Translocation Carriers

• Lee CI
• Lee SG
• Kim YJ
• Oh SJ
• Kim HS
• Choi KJ
• Lee KH

Abstract

Retrospective analysis of chromosomal abnormalities was performed on 75 couples who had recurrent spontaneous abortion. Karyotyping of their peripheral blood lymphocytes was made on 75 patients and 75 their husbands. The overall incidence of chromosomal aberrations was 22.7 %(17 in 75 couple). Number of chromosomal abnormalities in wives was twelve. Another chromosomal abnormalities were found in five husbands. All of them were balanced form and their phenotypes were normal. The incidence of translocations among total chromosomal abnormalities was 64.7 % (11/17). The incidence of reciprocal translocation(72.7 %) was higher than that of Robertsonian translocation (27.3 %). There were six other abnormalities including one case of inversion and five cases of polymorphisms. amniocentesis or chorionic villi sampling was performed during subsequent pregnancy to couples who had balanced chromosomal abnormalities. The karyotypes were classified as balanced translocation in seven cases, inversion in one case and normal karyotype in one case. This study suggests that prenatal diagnosis should be emphasized in couples in which one person is the carrier of a balanced chromosomal abnormality.

Keyword

Balanced chromosome translocation; Cytogenetics

MeSH Terms

Abortion, Spontaneous
Amniocentesis
Chorionic Villi Sampling
Chromosome Aberrations
Cytogenetics*
Diagnosis*
Family Characteristics
Female
Humans
Incidence
Karyotype
Karyotyping
Lymphocytes
Phenotype
Pregnancy
Prenatal Diagnosis
Retrospective Studies
Spouses