Korean J Pediatr Hematol Oncol.  2001 Oct;8(2):349-354.

CD68 Positive Histiocytic Necrotizing Lymphadenitis

• Park JA
• Park E
• Jang SJ
• Park SB
• Kim HS
• Ju HC
• Lee SS

Abstract

Histiocytic necrotizing lymphadenitis (Kikuchi's disease) is a cause of benign lymphadenitis, most commonly affecting young women and usually presenting as a painless or painful cervical lymphadenopathy sometimes associated with fever and leukopenia. Less frequent symptoms include weight loss, nausea, vomiting, and night sweats. We experienced two cases of histiocytic necrotizing lymphadenitis in an 11-year-old boy and a 13-year-old boy. They presented cervical lymphadenopathy with fever in one patient and without fever in the other patient. Lymph node enlargement did not respond to antibiotics. We performed surgical biopsy of cervical lymph node which was consistent with histiocytic necrotizing lymphadenitis. In one patient CD8 T cells and CD68 histiocytes were shown in immunohistochemical stain. So we report two cases of histiocytic necrotizing lymphadenitis with brief review of the related literature.

Keyword

Cervical lymphadenopathy; CD68; Histiocytic necrotizing lymphadenitis; Kikuchi's disease

MeSH Terms

Adolescent
Anti-Bacterial Agents
Biopsy
Child
Female
Fever
Histiocytes
Histiocytic Necrotizing Lymphadenitis*
Humans
Leukopenia
Lymph Nodes
Lymphadenitis
Lymphatic Diseases
Male
Nausea
Sweat
T-Lymphocytes
Vomiting
Weight Loss
Anti-Bacterial Agents