Korean J Perinatol.  2008 Jun;19(2):167-173.

Clinical review of abnormal cervical cytology in pregnancy

Affiliations
  • 1Department of Obstetrics and Gynecology, Ilsin Christian Hospital, Busan, Korea. dsj0628@hanmail.net
  • 2Department of Pathology, Ilsin Christian Hospital, Busan, Korea.

Abstract

PURPOSE: This study was performed to evaluate the clinical significance of abnormal cervical cytology in pregnancy and the effectiveness of cytologic and colposcopic surveillance of these women.
METHODS
A retrospective analysis was conducted in pregnant women referred to the colposcopic clinic with abnormal cervical cytologic results above ASCUS between Jan. 2002 and Dec. 2007. The Initial colposcopy was performed at the end of 1st trimester. Cervical cytology and colposcopy were repeated once or twice during remaining period of pregnancy and at postpartum 6~8 weeks. Colposcopy directed cervical biopsies were taken in case of colposcopic abnormalities. Without evidence of invasion, no invasive procedure was attempted during pregnancy. Above CIN2 patients were treated postnatally. The postpartum diagnoses were compared to the worst antepartum impressions and initial cytologies.
RESULTS
One hundred three pregnant women were referred to colposcopic clinic for 5 years. There was no invasive cervical cancer antenatally. After delivery, 53 patients were followed up and 17 patients above CIN2 lesions treated. Two microinvasive squamous cell carcinoma and 1 invasive adenocarcinoma were found postnatally. In 33 initial ASCUS cytologies, there were 7 CIN2,3 lesions and 3 invasive cancers. One CIN3 was found in 13 LSIL cytologies. All 7 HSIL patients had CIN3 lesions. There were 2 microinvasive cancers postnatally in 17 antenatal CIN2,3 patients.
CONCLUSION
ASCUS cervical cytologic results in pregnancy have 30% possibility of CIN2,3 and cancer. LSIL results are normal in 85% and HSIL group 100% CIN3. Even though there is 12.5% risk of microinvasion in antenatal CIN2,3 lesions, noninvasive conservative management is reasonable.

Keyword

Cervical Cytology; Colposcopy; CIN; ASCUS; Pregnancy

MeSH Terms

Adenocarcinoma
Biopsy
Carcinoma, Squamous Cell
Colposcopy
Female
Humans
Postpartum Period
Pregnancy
Pregnant Women
Retrospective Studies
Uterine Cervical Neoplasms
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