Composite liver tumors: A radiologic-pathologic correlation

Nayyar, Megha; Imagawa, David K; Tirkes, Temel; Demirjian, Aram N; Houshyar, Roozbeh; Sandrasegaran, Kumar; Nangia, Chaitali S; Seery, Tara; Bhargava, P; Choi, Joon II; Lall, Chandana

Clin Mol Hepatol. 2014 Dec;20(4):406-410. 10.3350/cmh.2014.20.4.406.

Composite liver tumors: A radiologic-pathologic correlation

Affiliations

¹Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
²University of California, Irvine, Orange, CA, USA. clall@uci.edu
³Indiana University, Indianapolis, IN, USA.
⁴University of Washington, Seattle, WA, USA.
⁵Department of Radiology, College of Medicine, Seoul St.Mary's Hospital, the Catholic University of Korea, Seoul, Korea.

KMID: 2070261
DOI: http://doi.org/10.3350/cmh.2014.20.4.406

Abstract

Bi-phenotypic neoplasm refers to tumors derived from a common cancer stem cell with unique capability to differentiate histologically into two distinct tumor types. Bi-phenotypic hepatocellular carcinoma-cholangiocarcinoma (HCC-CC), although a rare tumor, is important for clinicians to recognize, since treatment options targeting both elements of the tumor are crucial. Imaging findings of bi-phenotypic HCC-CC are not specific and include features of both HCC and CC. A combination of imaging and immuno-histochemical analysis is usually needed to make the diagnosis.

Keyword

Hepatoceullular carcinoma; Cholangiocarcinoma; Bi-phenotypic tumors; Computed tomography, Magnetic resonance imaging

MeSH Terms

CA-19-9 Antigen/metabolism
Carcinoma, Hepatocellular/mortality/pathology/radiography
Cholangiocarcinoma/mortality/pathology/radiography
Humans
Liver Neoplasms/mortality/pathology/*radiography
Magnetic Resonance Imaging
Phenotype
Risk Factors
Survival Analysis
Tomography, X-Ray Computed
alpha-Fetoproteins/analysis
CA-19-9 Antigen
alpha-Fetoproteins

Composite liver tumors: A radiologic-pathologic correlation

Abstract

Keyword

MeSH Terms

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