Korean J Urol.  2014 Oct;55(10):629-635. 10.4111/kju.2014.55.10.629.

Current Status of Radical Prostatectomy for High-Risk Prostate Cancer

• Kang HW
• Lee JY
• Kwon JK
• Jeh SU
• Jung HD
• Choi YD

• KMID: 2069784
• DOI: http://doi.org/10.4111/kju.2014.55.10.629

Abstract

Despite the wide application of prostate-specific antigen-based screening leading to a profound stage migration in prostate cancer (PC), a significant percentage of men are still being diagnosed with clinically high-risk disease that requires aggressive treatment. Optimal management in these patients remains challenging, and strong advocates for radical prostatectomy (RP), radiotherapy, androgen deprivation therapy, and, increasingly, a multimodal approach abound. Currently, surgery for high-risk PC is frequently applied. RP offers an attractive opportunity for tumor excision either as a definitive management or as a first step in multimodal therapy. Nevertheless, this approach is still controversial. In this review, we discuss the current evidence for the role of RP in this clinical setting, including surgical considerations and outcomes. The role of robot-assisted RP, which is increasingly utilized in Korea in this clinical scenario, is discussed.

Keyword

Prostatectomy; Prostatic neoplasms; Survival; Treatment outcome

MeSH Terms

Combined Modality Therapy
Humans
Male
Prostatectomy/*methods
Prostatic Neoplasms/*surgery/therapy
Robotic Surgical Procedures/methods
Treatment Outcome

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