J Bacteriol Virol.  2015 Sep;45(3):262-271. 10.4167/jbv.2015.45.3.262.

Current Trends in Studies of Epstein-Barr Virus (EBV) Associated Gastric Carcinoma

• Lee M
• Ryu E
• Sung GH
• Shin YS
• Kim JG
• Kang BW
• Cho H
• Kang H

• KMID: 2068742
• DOI: http://doi.org/10.4167/jbv.2015.45.3.262

Abstract

EBV infection has been causally associated with incidence of many carcinomas. EBV-associated gastric carcinoma (EBVaGC) has been classified as a unique gastric carcinoma subset, suggesting EBV infection is related to the development of gastric cancer. In this study, general trends of EBVaGC studies for last half-decades were reviewed in several perspectives of clinical significance, virological importance and etiological interests. Throughout this comprehensive reviewing, new study trends of EBV and EBVaGC for next half-decades were suggested.

Keyword

Epstein-Barr virus; Human gastric carcinoma; Methylation; Prognosis

MeSH Terms

Epstein-Barr Virus Infections
Herpesvirus 4, Human*
Incidence
Methylation
Prognosis
Stomach Neoplasms

Figure

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  Figure 1. Oncogenic events to induce EBV-associated epithelial malignancies by EBV latent gene products. EBV gene products (in blue) induce malignancies by interrupting several anti-tumor activities and promoting various diverse oncogenic events in EBV infected epithelial cells.

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  Figure 2. Important characteristics of gastric carcinoma subtype. Gastric carcinoma (GC) were classified into four subgroups such as chromosomally instable GC, Epstein-Barr virus (EBV)-positive GC, genomically stable GC, and microsatellite instable GC. In particular, EBV-positive GC showed mutation in PIK3CA, overexpression of PD-L1/2, silencing of CDKN2A, and etc. EBV-CIMP and RTK stand for CpG-island methylation phenotype and receptor tyrosine kinase, respectively.

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