J Korean Neurol Assoc.  1991 Sep;9(3):323-331.

Alcoholic Peripheral Neuropathy

Affiliations
  • 1Department of Neurology, Seoul National University, Korea.
  • 2Department of Neurology, Dong A University, Korea.
  • 3Department of Neurology, Chung Buk National University, Korea.
  • 4Department of Pathology, Seoul National University, Korea.

Abstract

Nerve conduction studies and sural nerve biopsies were performed on 13 patients with alcoholic peripheral neuropathy. Most patients had sensory loss and tingling sensation below knees. Wernicke's encephalopathy and pellagra dermatitis were commonly associated. There was no evidence of demyelinating newcpathy in nerve conductoion studies. Myelinated fiber oounts showed loss of small and largetbers in all patients, retaining a bimodal distribution. Segmental denyelination was not found in all teased fibers. Electron microscopy confirmed axonal degeneration of myelinated andunmyelinated fibers with seconday myelin change.


MeSH Terms

Alcoholics*
Axons
Biopsy
Dermatitis
Humans
Knee
Microscopy, Electron
Myelin Sheath
Neural Conduction
Pellagra
Peripheral Nervous System Diseases*
Sensation
Sural Nerve
Wernicke Encephalopathy
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