J Korean Neurol Assoc.
1991 Sep;9(3):323-331.
Alcoholic Peripheral Neuropathy
- Affiliations
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- 1Department of Neurology, Seoul National University, Korea.
- 2Department of Neurology, Dong A University, Korea.
- 3Department of Neurology, Chung Buk National University, Korea.
- 4Department of Pathology, Seoul National University, Korea.
Abstract
- Nerve conduction studies and sural nerve biopsies were performed on 13 patients with alcoholic peripheral neuropathy. Most patients had sensory loss and tingling sensation below knees. Wernicke's encephalopathy and pellagra dermatitis were commonly associated. There was no evidence of demyelinating newcpathy in nerve conductoion studies. Myelinated fiber oounts showed loss of small and largetbers in all patients, retaining a bimodal distribution. Segmental denyelination was not found in all teased fibers. Electron microscopy confirmed axonal degeneration of myelinated andunmyelinated fibers with seconday myelin change.
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