Korean J Urol.  2005 Apr;46(4):341-346.

Expression of Osteopontin and Clusterin in Transitional Cell Carcinoma of the Bladder: Comparison to the Pathologic Stage

• Yoon JH
• Lee JH
• Yeom BW
• Won NH
• Yoon DK

Abstract

PURPOSE: This study was performed to evaluate the expressions of osteopontin (OPN) and clusterin in a transitional cell carcinoma (TCC) of the urinary bladder, and then compare their expression rates with the tumor invasiveness.
MATERIALS AND METHODS
Twenty-five superficial and 25 invasive TCC were used for immunohistochemical staining.
RESULTS
All 25 non-invasive TCC showed a strong positive reaction for OPN. Twenty of the invasive TCC showed a strong positive reaction for OPN, but 5 showed only a weak positive reaction. OPN expression was significantly decreased in the invasive TCC (p=0.02). Eighteen superficial TCC showed a weak positive reaction for clusterin, with 7 showing a negative reaction. Nine invasive TCC showed a strong positive reaction for clusterin, and 11 showed only a weak positive reaction. Five invasive TCC showed a negative reaction for clusterin. Clusterin expression was significantly increased in the invasive TCC (p=0.001).
CONCLUSIONS
These results may suggest that OPN and clusterin could be used as markers to predict the biological behavior of a TCC.

Keyword

Osteopontin; Clusterin; Bladder; Transitional cell carcinoma

MeSH Terms

Carcinoma, Transitional Cell*
Clusterin*
Osteopontin*
Urinary Bladder*
Clusterin
Osteopontin