Verapamil Intralesional Injection for Peyronie's Disease

Kim, Jong Il; Park, Nam CheoI

Abstract

Peyronie's disease is a distressing disorder that pathophysiology and therapeutic subset of this disease are fairly not established. We studied the effectiveness of verapamil for Peyronie's disease which intralesionally injected with lO mg verapamil every 2 weeks for lO injections or more in 12 men among 15 men with Peyronie's disease at Pusan National University Hospital from May 1995 to May 1996. The mean age was 55.7 year-old (range 30-68). One case had failed prior steroid intralesional injection and four cases had failed prior vitamin E oral medication. The mean volume of plaque was approximated with 7.5 MHz high frequency ultrasound at 3.7ml (range 0.1- 8.4). The plaque causes the penile curvature which was discovered by questioning or intracavernosal injection of prostaglandin E1 in 9 cases (64.3%). Penile pain was rapidly resolved in all preexisting lO cases (lOO%). Of cases with the penile curvature on erection, angulation was decreased in 3 cases (33.3%). The penile rigidity on erection was inquired to be improved more or less in 4 cases (44.4%) with desirable sexual performance. Plaque volume and consistency were reduced in 6 cases (50%). We concluded the verapamil intralesional injection is one of the effective nonoperative therapeutic modality for Peyronie's disease because of the beneficial effects including complete pain relief, modest improvements in penile curvature and erectile function, decreased plaque volume and avoidance of disease progression without no adverse reactions.