Korean J Urol.
1990 Apr;31(2):159-165.
Immunohistochemical Study with Carcinoembryonic Antigen in Experimental Bladder Tumor Induced by Administration of N-butyl-N-(4-hydroxybutyl)-nitrosamine
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- 1Department of Urology, College of Medicine, Seoul National University, Seoul, Korea.
Abstract
- Immunohistochemical study with carcinoembryonic antigen (CEA) by peroxidase-antiperoxidase (PAP) method in rat bladder tumor induced by administration of N-butyl-N-( 4-hydroxybutyl)- nitrosamine was performed to know the immunological cross reactivity between human bladder tumor and experimentally induced rat bladder tumor and to evaluate, if all, its role as an indicator of malignant potential in rat bladder tumor. The results revealed 6 false positive reactions regardless of their histologic types and gave us no meaningful informations about ongoing disease process.
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