A Clinical Observation on Reflux Nephropathy : Outcome of Renal Function in Vesicoureteral Reflux Patients with Proteinuria

Yoon, Jong Byung; Lee, Seung Chan

Abstract

We have followed up 13 cases of primary bilateral vesicoureteral reflux with proteinuria, of which 11 cases treated with antireflux surgery and 2 cases conservatively, on patients who were admitted to the Dept. of Urology, Pusan National University Hospital from Jan. 1974 to Dec. 1986 for one to 13 years of period. The results are as follows : 1. Most of cases in primary bilateral vesicoureteral reflux with proteinuria were associated with pyelonephritis. Also, in about two third of cases, the patients demonstrated high degree of bilateral vesicoureteral reflux with deteriorated renal function. 2. Of cases with deteriorated renal function in preoperative period, the operation had no beneficial effect on renal function. Also, in cases with conservative treatment, the renal function was further deteriorated and progressed to renal failure. Of cases associated with proteinuria and renal scar in preoperative period, all of them showed no improvement in renal scar with either conservative treatment or antireflux surgery. 3. Urinary tract infection was ameliorated with antireflux surgery in cases of vesicoureteral reflux with proteinuria and, furthermore, proteinuria was improved in a lot of cases. However, with conservative treatment, urinary tract infection and proteinuria showed no improvement.