Obstet Gynecol Sci.  2015 Sep;58(5):423-426. 10.5468/ogs.2015.58.5.423.

Adult granulosa cell tumor presenting with massive ascites, elevated CA-125 level, and low 18F-fluorodeoxyglucose uptake on positron emission tomography/computed tomography

  • 1Department of Obstetrics and Gynecology, Kyungpook National University Medical Center, Kyungpook National University School of Medicine, Daegu, Korea. gochong@knu.ac.kr
  • 2Department of Pathology, Kyungpook National University Medical Center, Kyungpook National University School of Medicine, Daegu, Korea.


Adult granulosa cell tumors (AGCTs) presenting with massive ascites and elevated serum CA-125 levels have rarely been described in the literature. An ovarian mass, massive ascites, and elevated serum CA-125 levels in postmenopausal women generally suggest a malignant ovarian tumor, particularly advanced epithelial ovarian cancer. AGCT has low 18F-fluorodeoxyglucose uptake on positron emission tomography/computed tomography due to its low metabolic activity. In the present report, we describe a case of an AGCT with massive ascites, elevated serum CA-125 level, and low 18F-fluorodeoxyglucose uptake on positron emission tomography/computed tomography.


Adult granulosa cell tumor; CA-125; 18F-fluorodeoxyglucose; Massive ascites; Positron emission tomography/computed tomography

MeSH Terms

Granulosa Cell Tumor*
Granulosa Cells*
Ovarian Neoplasms


  • Fig. 1 (A) Computed tomography showing a 15×14×13 cm3 well-defined solid pelvic mass including a cystic component (arrow) with massive ascites. (B) 18F-fluorodeoxyglucose positron emission tomography/computed tomography showing low peripheral 18F-fluorodeoxyglucose uptake (maximum standardized uptake value 2.1, arrow).

  • Fig. 2 (A) Gross findings of the left ovarian tumor. (B, C) Histopathological features of the tumor cells (hematoxylin and eosin stain; B, ×100; C, ×400). (D-F) Immunohistochemical staining of the tumor cells (D, calretinin; E, alpha-inhibin; F, cytokeratin 7; D-F, ×200).


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