J Korean Acad Rehabil Med.  2008 Jun;32(3):294-299.

The Effects of Dilution Volume of Botulinum Toxin A on the Spasticity of Children with Cerebral Palsy

Affiliations
  • 1Department of Rehabilitation Medicine, Hanyang University College of Medcine, Korea. stephan72@hanmail.net

Abstract


OBJECTIVE
To evaluate the effects of the dilution volume of botulinum toxin A on spasticity of children with cerebral palsy. METHOD: Total 18 legs of 9 children with cerebral palsy were enrolled. 100 units of botulinum toxin were diluted with 4 cc or 2 cc of normal saline and injected to the medial and lateral heads of Gastrocnemius. Modified Ashworth scale, modified Tardieu test and range of motion (ROM) of ankle and knee were measured. Measurements were obtained before and at 1, 7, 14, 30, 60, 90, and 180 days after injection, respectively.
RESULTS
Spasticity tested by modified Ashworth scale and modified Tardieu test decreased and ROM of ankle and knee increased after 14 days since injection in both groups (p<0.05). In low dilution group, maximal ROM of ankle and knee was obtained at 30th day after injection. In high dilution group, maximal ROM of ankle and knee was achieved at 14th day after injection and maximal ROM of knee at 30th day after injection. However, there was no significant differences between high dilution group and low dilution group in different times.
CONCLUSION
Management of spasticity with botulinum toxin in cerebral palsy was not related to dilution volume.

Keyword

Cerebral palsy; Botulinum toxin A; Spasticity; Children; Dilution

MeSH Terms

Animals
Ankle
Botulinum Toxins
Cerebral Palsy
Child
Head
Humans
Knee
Leg
Muscle Spasticity
Range of Motion, Articular
Botulinum Toxins
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